Low-Pass Whole Genome Sequencing
Low-pass whole genome sequencing (also referred to as LP-WGS or shallow whole genome sequencing) is an inexpensive, high-throughput, DNA-sequencing technology used to accurately detect genetic variation within the genomes of a multitude of species. In addition to being an inexpensive alternative to genotyping arrays, LP-WGS enables the discovery of new rare variants with higher statistical power and provides an order of magnitude more data. From complex-trait association studies to calculation of genome-wide polygenic risk scores, low-pass whole genome sequencing can be used in multiple ways to address questions involving statistical and population genetics.