Targeted Sequencing
Targeted sequencing uses next generation sequencing to target specific genes, coding regions of the genome, or chromosomal segments for rapid identification and analysis of genetic mutations. Whether you want to pinpoint a few genes or a few hundred, our custom targeted sequencing panels offer high sensitivity and specificity, providing in-depth coverage and high-quality data to discover point mutations, insertions/deletions (INDELs), copy number variations (CNVs), and gene rearrangements.
Targeted sequencing is useful for studying gene variants in selected genes or specific regions of the genome, since a large diversity of organisms is targeted rapidly and cost-effectively. To investigate the location and frequency of vector integration in the host genome following transduction, use our integration site analysis (ISA) solution for pre-clinical and clinical cell and gene therapy research.
Targeted Sequencing Gene Panels
GENEWIZ provides a variety of targeted resequencing panels, either pre-made or custom, that can cover any genes of interest or cancer-implicated genes. Visit these pages to learn more about these services:
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Cancer Panels
Including commercially available hotspot cancer panels, as well as GENEWIZ pan-cancer and OncoGxOne™ discovery cancer panels.
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TargetGxOne™ (Custom Targeted Sequencing)
Our custom panels can be designed to target any genes of your choosing.
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Whole Exome Sequencing
A cost-effective alternative to whole genome sequencing, which allows genetic analysis of genomic coding regions.
Targeted Sequencing Applications
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Discover genetic biomarkers associated with disease state
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Characterize genetic associations to a particular phenotype, such as drug response
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Genotype and classify eukaryotic and/or prokaryotic cell lines
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Design genetic tests, such as for pharmacogenomics or oncology
Targeted Sequencing Features & Benefits
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Extensive multiplexing flexibility enables a more cost-effective assay
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Dedicated, on-going support from experienced GENEWIZ scientists
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In-house pipeline for optional Sanger-based confirmatory sequencing of final targets utilizing your NGS samples
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Comprehensive bioinformatics options for robust downstream analysis
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Availability of the most cutting-edge sequencing platforms
Sample Submission Guidelines
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Purified genomic DNA
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Frozen cell pellets (mammalian or bacterial)
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PCR amplicons
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Bacterial colonies
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Formalin-fixed, paraffin-embedded (FFPE) thin sections (slides)
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Select tissues
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Blood
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Swab
Technical Resources
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Blog | NGS, PCR, or Sanger Sequencing: An Assay Selection Guide
This selection guide offers practical information about PCR + Sanger, qPCR, and NGS approaches to help you determine which assay best suits your project requirements, along with an interactive assay selection tool to aid your decision making.
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Webinar| Non-Classical Sources of Tumour-Specific Antigen in Checkpoint Inhibitor Response
Developing immunotherapies for cancer can be difficult due to the variation of immune response from patient to patient. In this webinar, Dr. Litchfield from UCL Cancer Institute presents his team’s exploratory research using a multiomics approach to better understand the diversity of immune response to cancer and highlights their findings of an alternative source of a tumour-specific antigen in checkpoint inhibitor (CPI) response.
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Webinar| Demystifying End-to-End DNA Sequencing Solutions
In this co-hosted webinar with Twist Bioscience, learn how researchers design custom panels to sequence deeply and efficiently into regions, genes, and organisms of interest, as well as gain a greater understanding on how targeted sequencing can be combined with the latest transcriptomics and proteomics tools to reveal even more insights.
NGS Platforms
For information on our NGS platforms as well as recommended configurations of your projects, please visit the NGS Platforms page. GENEWIZ does not guarantee data output or quality for sequencing-only projects.
