EXOME SEQUENCING

 

Whole exome sequencing (WES) is a powerful tool to investigate genetic variations underlying cancers, Mendelian diseases, and complex human disorders. Targeting only protein coding regions, WES provides a more cost-effective approach than whole genome sequencing.

GENEWIZ provides comprehensive solutions for exome sequencing at the research and clinical level.

 

 

Exome Sequencing Coverage For Any Application

  • 50x coverage
    (~5 Gb output)

    Germline variant discovery
    Uncovering disease-associated genotypes

  • 100x coverage
    (~10 Gb output)

    Somatic mutation discovery
    Tumor/normal sequencing

  • ≥200x coverage
    (20+ Gb output)

     Low frequency mutation detection
    Measuring tumor mutational burden (TMB)

Features & Benefits

  • Superior Data Quality

    Superior Data Quality

    Exceeding manufacturer's benchmarks


  • Fast Turnaround

    Starting at 1 week for sequencing


  • European Provider

    Sequencing available at our lab in Leipzig, Germany

Dedicated Ph.D. -level support at every step with real-time project updates through our online system


Flexible data amounts starting at 10M read pairs


Latest platforms - Illumina NovaSeq delivers the highest throughput on the market


Highly scalable - Submit one sample or as many as hundreds

More reasons to choose GENEWIZ

Exome Sequencing Workflow

1. Hybridization Capture

Fragment gDNA, bind probes to exons, and pull down

2. Library Preparation

Add adapters to exon-enriched DNA

3. Sequencing

Sequence 2x150 bp on Illumina® platform

4. Data Analysis

Identify SNVs, INDELs, gene fusions, and CNVs