Ribonucleic acid (RNA) oligonucleotides (oligos) are short, single- or double-stranded synthetic RNA sequences that can serve as the starting point for many molecular biology and synthetic biology applications.
Locked nucleic acids (LNAs) are bicyclic nucleotide derivatives that have garnered interest in fundamental research and discovery applications. A carbon bridge is tethered between the 2’ oxygen and the 4’ carbon to lock the sugar’s conformation and prevent alternative endo or exo ring configurations.
The conformational inflexibility of the ribose moiety offers superior affinity for complimentary nucleotides and increased proteolytic resistance. These characteristics make LNA monomers ideal alternatives for RNAs as primers, probes, and therapeutic agents for in-situ hybridization detection, antisense oligos, and microRNA constructs.
Talk to an Azenta project manager to learn more.
RNA oligonucleotides are provided as a dry powder, fully lyophilized after RNase-free HPLC purification, in as few as 3 days. Below is a summary of what to expect from your order.
|Oligo Type||Synthesis Length||Purified Synthetic Yield||Turnaround Time*||Quality Control|
|Short RNA Oligos (including LNA)||6-70 nt||1-150 nmol||In as few as 3 days||
- Certificate of analysis (CoA)
- LCMS report
- HPLC report (optional)
|Long RNA Oligos (including sgRNA)||up to 140 nt||1.5-10 nmol||In as few as 2 weeks|
*Large orders may require additional turnaround time. Please contact our Ph.D. technical support team for more information about large or custom inquiries.