ANTIBODY DISCOVERY SOLUTIONS

From Discovery to Pre-Clinical Development

INTRODUCTION

Antibody-based therapeutics have entered the center stage of drug discovery as a result of a major shift in focus from small molecules to a broader portfolio containing both protein and chemical therapeutic agents. The field is benefiting from both an increased understanding of the mechanistic basis of antibody-derived therapeutics and the development of sophisticated technologies to derive safe and targeted biotherapeutics.

Antiobody

ANTIBODY DISCOVERY WORKFLOW

Library Generation
Lead Identification
Lead Optimization
Pre-Clinical Development

GENEWIZ offers the latest sequencing technologies and customizable synthetic DNA solutions to expedite your discovery process while keeping the cost low.

Check out GENEWIZ antibody solutions below to help you with each step of the discovery process.

Step 1: Library Generation

Synthetic DNA Solutions

Synthetic DNA Libraries

provide highly diverse synthetic variant and combinatorial libraries with unprecedented flexibility to customize amino acid diversity to optimize your antibody discovery process.

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Gene Synthesis

Next Generation Sequencing

Diversity Assessment

via Amplicon Sequencing provides a comprehensive diversity analysis of your synthetic antibody DNA libraries.

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Next Generation Sequencing

Step 2: Lead Identification

Molecular Genetics

PCR + Sanger Assay

offers a full-service solution to facilitate the screening and confirmation of heavy chain/ light chain sequences.

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Molecular Genetics

Sanger Sequencing

Direct Colony Sequencing

enables rapid phage analysis of isolated antibody clones after a bio-panning affinity selection.

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Sanger Sequencing

Next Generation Sequencing

Amplicon Sequencing

offers identification of highly diverse leads after bio-panning enrichment.

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Amplicon Sequencing

 

Immuno-Profiling

provides comprehensive analysis of in vivo repertoires after immunization.

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Immuno Profiling

Step 3: Lead Optimization

Synthetic DNA Solutions

Antibody DNA Synthesis

offers fully codon-optimized synthetic antibody constructs for recombinant antibody expression starting at just 6 business days.

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Gene Synthesis

Sanger Sequencing

Colony Sequencing + Plasmid DNA Prep

offers a full-service solution to directly sequence bacterial clones followed by large-scale DNA preparation for recombinant antibody expression.

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Sanger Sequencing

CRISPR Solutions

Genome Editing and Engineering

offers a wide range of synthetic DNA solutions and sequencing-based solutions for creating transgenic cell lines.

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CRISPR

 

Long Single-Stranded DNA Synthesis

enables CRISPR-mediated gene knock-in to integrate recombinant V(D)J region to generate transgenic models for antibody production.

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Single Strand DNA Synthesis

Step 4: Pre-Clinical Development

GLP-Compliant Services

GLP-Compliant Sequencing

of antibody-producing cell lines for FDA level submissions and confirmation of manufactured cell banks throughout the clinical pipeline.

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GLP-Compliant Sequencing

 

GLP-Compliant Plasmid Prep Services

offer a range of DNA preparation solutions to accelerate research and pre-clinical development for antibody drug discovery.

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GLP-Compliant Plasmid Prep Services

Next Generation Sequencing

Whole Genome Sequencing

provides a comprehensive validation of antibody-expressing cell lines on multiple sequencing platforms.

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Whole Genome Sequencing

THE GENEWIZ DIFFERENCE

Stringent Quality Control

Stringent Quality Control

Optimized workflows and technical expertise produce consistent results with best-in-class quality. GLP, CLIA, and CAP services are available.

Turnaround Time

Industry-leading Turnaround Time

DNA sequencing and synthesis delivered when you need it with expedited options for many services.

Technical Support

Unparalleled Technical Support

Ph.D.-level consultation provides guidance before, during, and after the project.

Partner of Choice

Partner of Choice

Over 600 pharmaceutical and biotechnology companies have trusted us with their projects.

CONTACT GENEWIZ

Ph.D.-level experts are available to discuss your project. Call us today at 877-436-3949.

Next Generation Sequencing Ext. 1 • ngs@genewiz.com

Sanger Sequencing Ext. 2 • dnaseq@genewiz.com

Synthetic DNA Solutions Ext. 3 • pm@genewiz.com

Molecular Genetics Ext. 3350 • molgen@genewiz.com

GLP-Compliant Services Ext. 3350 • regulatory@genewiz.com