EPIGENOMICS SOLUTIONS

 

The epigenome encompasses chemical modifications to DNA and histone proteins, chromatin accessibility, and higher-order DNA organization. Its profound effect on gene regulation, and consequently development and pathogenesis, is only beginning to be understood. Although epigenetic modifications do not alter the nucleic acid sequence itself, sequencing-based techniques can detect them indirectly.

As a leading provider of next generation sequencing (NGS), GENEWIZ offers a suite of powerful NGS solutions, including whole genome bisulfite sequencing (WGBS), to rapidly and thoroughly analyze the epigenome of many organisms.

Now accepting plant tissue!


  

Service Options

Whole Genome Bisulfite Sequencing


Whole genome bisulfite sequencing (WGBS) provides robust, global detection of 5-methylcytosine (5mC), a common form of DNA methylation in eukaryotes.

PacBio® Methylation Sequencing


Whole genome sequencing on the PacBio® Sequel® can reveal a diverse array of DNA modifications, including 6-methyladenine (6mA) and 4-methylcytosine (4mC), as well as perform haplotype phasing of epigenetic markers.

ATAC-Seq


Assay for transposase-accessible chromatin sequencing (ATAC-Seq) employs Tn5 transposase to identify open chromatin with a higher signal-to-noise ratio and lower input requirements than other approaches.

ChIP-Seq


Chromatin immunoprecipitation sequencing (ChIP-Seq) identifies protein-DNA interactions and histone modifications across the genome, producing data with better resolution, less noise, and higher coverage than array-based technologies.

Single-Cell ATAC-Seq


Single-cell ATAC-Seq (scATAC-Seq) identifies genome-wide chromatin accessibility by profiling single cells in parallel, allowing researchers to examine how chromatin structure and DNA-binding proteins regulate gene expression in varying states and cellular processes.

How To Order


Email | Phone (1-877-GENEWIZ (436-3949), Ext. 1)