The epigenome encompasses chemical modifications to DNA and histone proteins, chromatin accessibility, and higher-order DNA organization. Its profound effect on gene regulation, and consequently development and pathogenesis, is only beginning to be understood. Although epigenetic modifications do not alter the nucleic acid sequence itself, sequencing-based techniques can detect them indirectly.

As a leading provider of next generation sequencing (NGS), GENEWIZ offers a suite of powerful NGS solutions, including Whole Genome Bisulfite Sequencing (WGBS), to rapidly and thoroughly analyze the epigenome of any organism.

Service Options


Methylation Sequencing, including Whole Genome Bisulfite Sequencing, enables comprehensive analysis of genome-wide methylation at single-base resolution.


Assay for Transposase-Accessible Chromatin using Sequencing (ATAC-Seq) employs Tn5 transposase to identify open chromatin with a higher signal-to-noise ratio and lower input requirements than other approaches.


Chromatin Immunoprecipitation Sequencing (ChIP-Seq) identifies protein-DNA interactions and histone modifications across the genome, producing data with better resolution, less noise, and higher coverage than array-based technologies.



  • Customizable assays to target diverse array of methylated bases, including 5mC, 6mA and 4mC

  • Long-read sequencing on the PacBio® Sequel® to phase methylation calls


  • Highest throughput sequencing on the Illumina® NovaSeq delivers the most cost-effective assay

  • Optimized bioinformatics for ATAC-Seq data


  • Ultra-low input requirements as low as 10 ng

  • Extensive experience working with ChIP DNA

How To Order

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