OncoGxOne™ Discovery Cancer Panels

GENEWIZ OncoGxOne™ Discovery cancer panels provide comprehensive genomic analysis for cancer research, biomarker discovery, and patient stratification. Designed and developed with the most recent research data available, these assays provide thorough assessments on cancer genes of interest.  For additional information, please refer to our OncoGxOne™ Discovery Cancer Panels FAQ.


Request Quote
  Why GENEWIZ   
Building

Applications

Cancer mechanism studies, such as identifying novel driving mutations
Cancer therapeutic target discovery
Cancer biomarker discovery
Patient stratification
Personalized cancer treatment

Features & Benefits


19 cancer-type specific panels

Each panel assays a range of 150-400 tumor-specific genes, providing flexibility of adding or subtracting genes of your liking

Panels target full exonic and UTR regions, as well as select intronic regions implicated in breakpoints

Designed and verified to provide thorough coverage of specific cancer loci of interest

Ability to detect all types of genomic aberrations, including SNPs, INDELS, rearrangements, and CNVs

Extremely high depth of coverage to detect common and rare mutations

Very low input DNA requirement

Sequencing compatibility with FFPE samples


Customizability of cancer panels to add additional genes of interest

Complete solution, from project design through custom data analysis

Fast turnaround time with expedited options available

Cancer Types Assayed by GENEWIZ OncoGxOne™ Discovery Panels*

  • Bladder Cancer
  • Brain Cancer
  • Breast Cancer
  • Cervical Cancer
  • Colorectal Cancer
  • Endometrial Cancer
  • Lung Cancer
  • Lymphoma
  • Melanoma
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Thyroid Cancer

*Development of assays for other cancer types with flexibility to add or subtract genes from premade panels available upon request.



Cancer Panel Comparison


GENEWIZ OncoGxOneTM
Discovery Cancer Panels
Illumina TruSeq©
Amplicon Cancer Panel
Ion AmpliSeqTM
Cancer Hotspot Panel
Sequencing Platform Illumina MiSeq or HiSeq Illumina MiSeq Ion PGM®
Cancer Types Assayed 19 distinct gene panels, each assays a specific cancer (organ) type Single gene panel assays multiple cancer types Single gene panel assays multiple cancer types
Genes Covered ≈150 - 400 48 50
Genomic Variation Detection
  • Point Mutations
  • Indels
  • Rearrangements
  • Copy Number Variations (CNV)
  • Point Mutations
  • Indels
  • Point Mutations
  • Indels
Target Regions ≈ 2 - 5.4 Mb, consisting of all exons, UTRs, and relevant intron regions ≈35 Kb, consisting of mutational hot spots ≈ 39 Kb, consisting of mutational hot spots
Average Depth > 100x* > 100x* > 100x*
Target Enrichment Agilent SureSelect Targeted Enrichment Illumina Targeted Amplicon Sequencing Life Technologies Targeted Amplicon Sequencing
DNA Input > 100 ng > 250 ng > 10 ng
Sample Submission
  • FFPE thin sections (slides)
  • gDNA
  • Fresh, frozen samples
  • FFPE thin sections (slides)
  • gDNA
  • FFPE thin sections (slides)
  • gDNA
*Additional depth of coverage is available by request.

Sample Submission Guidelines

GENEWIZ accepts formalin-fixed, paraffin-embedded (FFPE) thin sections (slides), purified genomic DNA, or fresh, frozen samples for Cancer Panel projects. For detailed sample submission requirements please visit our Sample Submission Guidelines page.


Deliverables

All customers receive their raw data as FASTQ files. Mutation discovery and customizable data analysis packages are available by request.


NGS Platforms - Now with ILLUMINA Novaseq

GENEWIZ is a certified service provider for Illumina NGS platforms and the PacBio Sequel. Please visit our NGS Platforms page for more information.



How To Order


Email | Phone (1-877-GENEWIZ (436-3949), Ext. 1) | Live Chat