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Cancer panels use next generation sequencing (NGS) technology to target specific genes or mutations that have established relevancy to a particular cancer phenotype. NGS facilitates sequencing of large genomic regions, high numbers of genes, and/or high numbers of samples in a single, efficient and cost-effective assay. In addition, NGS provides significantly higher sensitivity than traditional techniques, which permits the discovery of rare somatic mutations, many of which have been identified as important cancer drivers.
GENEWIZ offers a number of different cancer panels to provide a complete solution from experimental design to advanced bioinformatics analysis.
SERVICE OPTIONS
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OncoGxOne™ Discovery Cancer Panels
GENEWIZ OncoGxOne™ Discovery cancer panels provide comprehensive genomic analysis for cancer research, biomarker discovery, and patient stratification for clinical discovery. Designed and developed with the most recent research data available, these assays provide thorough assessments on cancer genes of interest.
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Hotspot Cancer Panels
Hotspot cancer panels target well-characterized, small regions of known cancer genes. The small target region size produces a high depth of sequencing coverage per sample, even when multiplexing many samples together. As a result, hotspot cancer panels provide a cost-effective and efficient method for discovering rare somatic mutations, many of which have been identified as important cancer drivers.
Features & Benefits
Cancer Panel Comparison
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GENEWIZ OncoGxOneTM Discovery Cancer Panels |
Illumina TruSeq© Amplicon Cancer Panel |
| Sequencing Platform | Illumina MiSeq or HiSeq | Illumina MiSeq |
| Cancer Types Assayed | 19 distinct gene panels, each assays a specific cancer (organ) type | Single gene panel assays multiple cancer types |
| Genes Covered | ≈150 - 400 | 48 |
| Genomic Variation Detection |
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| Target Regions | ≈ 2 - 5.4 Mb, consisting of all exons, UTRs, and relevant intron regions | ≈35 Kb, consisting of mutational hot spots |
| Average Depth | > 100x* | > 100x* |
| Target Enrichment | Agilent SureSelect Targeted Enrichment | Illumina Targeted Amplicon Sequencing |
| DNA Input | > 100 ng | > 250 ng |
| Sample Submission |
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Sample Submission Guidelines
GENEWIZ accepts formalin-fixed, paraffin-embedded (FFPE) thin sections (slides), purified genomic DNA, or fresh, frozen samples for Cancer Panel projects. For detailed sample submission requirements please visit our Sample Submission Guidelines page.Deliverables
All customers receive their raw data as FASTQ files. Mutation discovery repeats and customizable data analysis packages are available on request.
NGS Platforms - Now with ILLUMINA Novaseq
GENEWIZ is a certified service provider for Illumina NGS platforms and the PacBio Sequel. Please visit our NGS Platforms page for more information.
