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Metagenomic sequencing includes a suite of solutions ranging from targeted assays (16S for prokaryotes and ITS2 for fungi) to shotgun sequencing and metagenomic analysis. Metagenomics can leverage next generation sequencing (NGS) to rapidly analyze the diversity of microbial communities and elucidate the role of constituent species.
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What is metagenomic sequencing?
Metagenomic sequencing is the collective analysis of all genomic material present in a sample (containing mixed microorganism communities), thus eliminating the need for isolating and cultivating individual organisms.
What is metagenomics vs. genomics?
Both metagenomics and genomics are fields of study within molecular biology, but the difference is in scope. While genomics is focused on the genome of a single organism, metagenomics encompasses all genomes of various microorganisms within a single given sample, providing a broad overview of an ecosystem’s composition.
Metagenome Sequencing Service Options
| 16S-EZ | Fungal Identification | Whole Genome Metagenomics | |
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Microbes Targeted |
Bacteria and Archaea | Fungi | All |
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Taxon Level |
Genus/Species | Genus/Species | Sub-species |
| Genomic Loci Sequenced | 16S rRNA gene (V3 and V4 regions) |
Internal Transcribed Spacer 2 (ITS2) |
Whole Genomes |
| Purpose of Assay | Taxon Identification |
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| Benefits | Enhanced sensitivity outperforms V4-only assays |
High variation in ITS2 region allows differentiation between closely related species |
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| Available Reports |
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Coming soon! Full-length 16S sequencing for sub-species resolution. Please inquire for more details.
Features & Benefits
TECHNICAL DETAILS
Example Report: 16S-EZ Metagenomics Bioinformatics Analysis
With the addition of the new, enhanced bioinformatics analysis and report, 16S-EZ delivers industry-leading analysis of microbiome diversity and composition. This improved report takes the tedium out of dendrogram and graph creation, allowing you to analyze your data faster. An example report is available for viewing by clicking the button below.
The enhanced report includes the following information:
- Rank-abundance curve
- Taxonomic classification
- Rarefaction curve
- Principal coordinate analysis
- Hierarchical clustering
Tech Note: 16S MetaVx™ Environmental Detects Greater Prokaryotic Diversity Than Traditional 16S Assay
We compared GENEWIZ’s 16S MetaVx Environmental service against a traditional V4-only assay. 16S MetaVx Environmental consistently detected a greater number of bacteria and archaea, demonstrating its superior sensitivity and specificity.
Download Now
Webinar | Understanding biological mechanisms to better predict the evolution of antibiotic resistance
The rapid and wide-spread evolution of antibiotic resistance is threatening global health. In this webinar, presented by Dr. Mato Lagator, Wellcome Trust, Royal Society Sir Henry Dale Fellow, University of Manchester, you will learn about different approaches to study evolutionary processes that underpin the emergence of resistance. Special focus is given on how these methods can be utilized to improve drug development and longevity.
Watch NowSample Submission Guidelines
GENEWIZ accepts a variety of starting materials for Metagenomics projects. For detailed sample submission requirements please visit our Sample Submission Guidelines page.
Certified Illumina Sequencing Provider
Azenta is a certified service provider for Illumina and Life Technology NGS platforms. For information on our NGS platforms as well as recommended configurations for your projects, please visit the NGS Platforms page. Azenta does not guarantee data output or quality for sequencing only projects.
