ATAC-Seq (assay for transposase-accessible chromatin sequencing) identifies open chromatin regions and efficiently labels them for high-throughput sequencing. This technique has a higher signal-to-noise ratio and lower input requirements than similar approaches.
Our ATAC-Seq service, from library preparation to data analysis, provides an optimized approach for nuclei extraction from cryopreserved cells to ensure detailed insight into genome-wide chromatin accessibility. If you want to understand gene expression regulation at the individual-cell level in varied states and cellular processes, we also offer single-cell ATAC-Seq (scATAC-Seq).
Isolate and freeze cells with protocol provided by Azenta
If low viability, live cells are enriched using a magnetic bead-based approach
Optimized ATAC assay produces robust signal from low inputs
Guaranteed data quality exceeds Illumina® benchmarks
Alignment, peak calling, and multiomic data integration
Assay for transposase-accessible chromatin sequencing (ATAC-Seq) employs a hyperactive form of Tn5 transposase to identify regions of open chromatin, which are important for global epigenetic control of gene expression. Tn5 simultaneously cleaves and adds adapters to nucleosome-free regions of DNA, priming them for sequencing.
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